Histology Study of Liver Changes Paracetamol-Induced Wistar Rats Treated with Sunkist (Citrus sinensis L. Osbeck) Extract
Keywords:hepatitis, Citrus sinensis, copper, degeneration
Unclear and high incidence and prevalence of hepatitis over the world. The peels extract of Citrus sinensis is riched in various phytochemical compound which may have antioxidant effects. This study is aimed to investigae the protection effect of ethanol extract from Citrus sinensis by histologic study of liver tissues in paracetamol-induced wistar rats. This study was using 15 rats which were divided into 5 groups included negative control, positive control, and ethanol extract groups (300 mg/kg b.w; 450 mg/kg b.w; 600 mg/kg b.w), after 14 days the rats was terminated and the liver was process to histology view. The result of this study showed that there was reducing in severity of degeneration following increasing of ethanol extract dosage. Based on the result study, ethanol extract of Citrus sinensis potentially has liver protection against paracetamol at highest dosgae by histology study.
Kemenkes RI, ‘InfoDatin Situasi dan Analisis Hepatitis’. Pusat Data dan Informasi Kemenkes RI, Jakarta, 2014.
I. Loho and I. Hasan, ‘Drug-Induced Liver Injury – Tantangan dalam Diagnosis’, Contin. Med. Educ., vol. 41, no. 3, pp. 167–170, 2014.
P. Bayupurnama, ‘Hepatotoksisitas Imbas Obat’, in Buku Ajar Ilmu Penyakit Dalam Jilid I Edisi VI, 6th ed., S. Setiati, I. Alwi, A. W. Sudoyono, M. Simadibrata, B. Setiyohadi, and A. F. Syam, Eds. Jakarta: Interna Publishing, 2017, pp. 2009–2014.
Badan Penelitian Dan Pengembangan Kesehatan Kementerian Kesehatan RI, ‘Riset Kesehatan Dasar 2013’, 2013.
Kemendagri, ‘Obat Herbal Tradisional’, War. Ekspor, no. September 2014, pp. 1–20, 2014.
S. Dalimartha and F. Adrian, Ramuan Herbal Tumpas Penyakit. Jakarta: Penebar Swadaya, 2013.
B. Mehmood et al., ‘In vitro assessment of antioxidant, antibacterial and phytochemical analysis of peel of Citrus sinensis’, Pak. J. Pharm. Sci., vol. 28, no. 1, pp. 231–239, 2015.
E. Etebu and A. B. Nwauzoma, ‘A Review On Sweet Orange (Citrus Sinensis L Osbeck): Health, Diseases And Management’, Am. J. Res. Commun., vol. 2, no. 2, pp. 33–70, 2014.
S. S. Liew, W. Y. Ho, S. K. Yeap, and S. A. Bin Sharifudin, ‘Phytochemical composition and in vitro antioxidant activities of Citrus sinensis peel extracts’, PeerJ, vol. 6, pp. e5331–e5331, Aug. 2018.
M. H. Ross and W. Pawlina, Histology a Text and Atlas. Philadelhia: Wolters Kluwer, 2011.
A. L. Meschel, Histologi Dasar Junqueira Teks & Atlas, 12th ed. Jakarta: EGC, 2017.
V. P. Eroschenko, Atlas Histologi diFiore Edisi Ke-12. Jakarta: EGC, 2015.
V. Kumar, R. S. Cotran, and S. L. Robbins, Buku Ajar Patologi Robbins, 9th ed. Jakarta: EGC, 2015.
H. Mohan, Textbook of Pathology Sixth Edition. New Delhi: Jaypee, 2010.
D. A. Bender, ‘Free Radicals & Antioxidant Nutrients’, in Harper’s Illustrated Biochemistry 30th Edition, New York: McGraw-Hill Education, 2015, pp. 564–568.
M. T. Lee, W. C. Lin, B. Yu, and T. T. Lee, ‘Antioxidant capacity of phytochemicals and their potential effects on oxidative status in animals - A review’, Asian-Australasian J. Anim. Sci., vol. 30, no. 3, pp. 299–308, 2017.
How to Cite
Authors who submit papers with this journal agree to the following terms.