Impact of Plasmodial Parasitaemia on the Quality of Erythrocyte Concentrates Distributed at the Blood Transfusion Center of the Regional Hospital of Bafoussam-Cameroon

Authors

  • Symphorien Ewodo Faculty of Medicine and Pharmaceutical Sciences, University of Dschang; National Center for Blood Transfusion Yaounde
  • Jeannette Yondo Faculty of Medicine and Pharmaceutical Sciences, University of Dschang.
  • Audrey Divine Kianpi Sonhafouo Dschang district hospital, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, d) Douala General Hospital, Higher institute of medical technologies of Yaoundé.
  • Clémence Olemba Douala General Hospital, Higher institute of medical technologies of Yaoundé.
  • Nadine sylvie Ongbayokolak Dschang district hospital, Department of Biochemistry,Faculty of Sciences, Biochemistry research unit of medicinal plants, Food Science and Nutrition. University of Dschang, P.O. Box 67, Dschang, Cameroon,
  • Michel Nouboum Dschang district hospital, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang,
  • Eveline Ngouadjeu Dongho Douala General Hospital, Faculty of Medicine and Pharmaceutical Sciences, University of Douala.

Keywords:

Bafoussam blood transfusion center, erythrocyte concentrate, plasmodial parasitaemia, quality

Abstract

Background: Blood transfusion is a potential route for transmission of Plasmodium, which lives mainly in erythrocytes and can survive low temperatures. Therefore, this study was undertaken in order to determine the plasmodial  parasitaemia in labile blood products for the evaluation of the quality of erythrocyte concentrates (EC) distributed at the Blood Transfusion Center of the Bafoussam Regional Hospital.

Material and methods: This was an analytical cross-sectional study carried out between March 15 and May 31, 2021 on 101 EC. The data collection was done on one hand by using a questionnaire and the technical sheet for the evaluation of the quality of the EC compared to the Cameroonian reference and on the other hand, by the analysis of the blood taken from the donors. This analysis was made through the examinations of RDT malaria, Thick blood smear, Thin blood smear, measurement of the hemoglobin level thanks to the HemoCue and hemogram using the Urit 3000 automaton. Data analysis was done using Epi info and SPSS software.

Results: The prevalence of malaria among donors of the Bafoussam Regional Hospital Blood Bank was 4.41%. By considering the three parameters simultaneously, a compliance rate of 34.65% was obtained. A positive, although non-significant, correlation was established between plasmodial parasitaemia and EC quality.

Conclusion: The importance of quality control of ECs is essential, sofar as the parasitaemia of plasmodial is not negligible with one bag of erythrocyte concentrate out of three non-compliant.

References

. MYG. Tazerout. (2016). "Manual for training in blood transfusion Regional Coordination of Haemovigilance." Available online :www. Haemovigilance.fr (accessed on 3 February 2022)

. C. NDO. (2019). "Hepatitis B and C, HIV, Syphilis Seroprevalences and Asymptomatic Carriage of Hemoparasites Among Blood Donors at the Douala General Hospital in Cameroon, Central Africa". Biomed J Sci Tech Res.18:13968–13974.

. S.Begue , M. Vidal-Obert , A. Girard , MP. Perrault, MC. Leroy , M. Masse, et al. (1999). " Quality control of labile blood products. Why and how to properly take a sample?" Transfus Clin Biol.. 6:403–408.

. F. Bruneel , M. Thellier , O. Eloy , D. Mazier , G. Boulard , M. Danis , et al. (2004)."Transfusion-transmitted malaria". Intensive Care Med. 30:1851–1852.

. AD. Kitchen ,PL. Chiodini. (2006) . "Malaria and blood transfusion". Vox Sang.90:77–84.

. M. Léger , O. Enama ,PA. Ntonga , AM. Mbida, NN. Takap , O. Etoile , et al. (2020). "Le paludisme : connaissances , attitudes et pratiques des chefs de ménage de la région de l'ouest - Cameroun". pp:1511715124.

. J. Christian , M. Barrère . (2002). " Malaria situation and malaria control strategies in Cameroon". pp:165–178.

. C . Tayou Tagny , D. Mbanya ,O. Garraud , JJ. Lefrère (2007)." Blood safety: malaria and blood donation in Africa". Transfus Clin Biol. 7(14):481–486. doi:10.1016/j.tracli.2007.12.003.

. D. Noubouossie , CT. Tagny , A. Same-Ekobo , D. Mbanya . (2012.) "Asymptomatic carriage of malaria parasites in blood donors in Yaoundé". Transfus Med. 22:63–67.

. EC. Okocha , CC. Ibeh , PU. Ele , NC. Ibeh . (2005). "The prevalence of malaria parasitaemia in blood donors in a Nigerian teaching hospital". J Vector Borne Dis. 42:21–24.

. E. Candolfi . (2005)."Transfusion transmitted malaria, preventive measures". Transfus Clin Biol. 12 2 SPEC. ISS.:107–113.

. JJ. Lefrère , PROUGER. (2011). " Blood transfusion ". Elsevier Masson. Available online :www. leslibrairiese.fr (accessed on 3 February 2021)

. Guide to the characteristics of labile blood products for Cameroon. 2019.

. C. Tayou Tagny , D. Mbanya , O. Garraud , JJ. Lefrère .(2007). 3Sécurité transfusionnelle : paludisme et don de sang en Afrique". Transfus Clin Biol. 14:481–486.

. WH. Schneider .(2013). "History of blood transfusion in sub-saharan africa. Transfus". Med Rev. 27:21–28. doi:10.1016/j.tmrv.2012.08.001.

. JO. Bassandja JO, SB. Agasa , JL. Likwela. ( 2014). " Prevalence of asymptomatic Plasmodium carriage among voluntary blood donors in Kisangani, Democratic Republic of Congo". Pan Afr Med J. 17. doi:10.11604/pamj.2014.17.320.3778.

. MB.Hoshen , AP. Morse . (2004) ."A weather-driven model of malaria transmission". 14:1–14.

. A. Rakoto .( 2019). "Asymptomatic carriage of Plasmodium in blood donors at the regional transfusion center of the Southern region of Madagascar Portage asyptomatique du Plasmodium chez les transfusion sanguine dans la règion Sud de Madagascar" ;21:2017–2020.

. TE. Kwenti , IA. Njunda , B. Tsamul , SD. Nsagha , NJC. Assob ,KA. Tufon, et al. (2017). "Comparative evaluation of a rapid diagnostic test, an antibody ELISA, and a pLDH ELISA in detecting asymptomatic malaria parasitaemia in blood donors in Buea, Cameroon" . Infect Dis Poverty. 6:1–9.

. KJ. Murphy , AL. Conroy , H. Ddungu ,R. Shrestha , D. Kyeyune-Byabazaire , MR. Petersen , et al. (2020). "Malaria parasitemia among blood donors in Uganda". Transfusion. 60:955–964.

. TT. Epidi , CD. Nwani , NP. Ugorji .(2008). "Prevalence of malaria in blood donors in Abakaliki metropolis, Nigeria". Sci Res Essays.3:162–164.

. LJ. Bruce-Chwatt . (1954). "Problems of malaria control in tropical Africa". Br Med J. 1:169–174.

. A. Adusei , A. Owusu-Ofori . (2018). "Prevalence of plasmodium parasitaemia in blood donors and a survey of the knowledge, attitude and practices of transfusion malaria among health workers in a hospital in kumasi, Ghana". Plos One. 13:1–12.

. JO. Bassandja ,SB. Agasa , JL. Likwela .(2014). "Prevalence of asymptomatic Plasmodium carriage among voluntary blood donors in Kisangani, Democratic Republic of Congo". Pan Afr Med J. 17:1–5.

. C. Lengeler , J. Pryce , M. Richardson ,(2018). " Insecticide-treated nets for preventing malaria". Cochrane Database Syst Rev. 3:18-20.

. D. Mbanya , B. Nouthe , C. Tayou Tagny , S. Moudourou , J. Ngogang .(2007). " Concentrated red blood cells transfusion in Yaoundé, Cameroon: What quality?" Transfus Clin Biol.14:453–456.

. E. Hussein , A. Enein . (2014). "Clinical and quality evaluation of red blood cell units collected via apheresis versus those obtained manually". Lab Med. 45:238–243.

. Pavenski Katerina. (2018). " Guide to transfusion practice". pp:1–19.

. R. Jovanović .(1995). "Evaluation of the quality control system in blood transfusion service". Med Pregl.1:1-6.

. DE. Nevalainen , HL. Lloyd .(1995). " ISO 9000 quality standards: a model for blood banking?" Transfusion. 35:521–524.

. R. Gniadecki , C. Assaf , M. Bagot , R. Dummer ,M. Duvic , R. Knobler , et al.( 2007). PAM J. 157:441–449.

. K. Nebie , S. Sawadogo , Kafando E, EM. Bationo , H. Dahourou ,S. Ouattara , et al.(2017). " Contributions of finished product quality control in improving the quality of labile blood products at the Ouagadougou Regional Blood Transfusion Center (Burkina Faso)". Transfus Clin Biol. 24:431–439. doi:10.1016/j.tracli.2017.05.002.

. H. Magnang , E. Padaro ,K. Mawussi ,T. Ouenangou , Y. Layibo , MDI. Kuéviakoé, et al.(2019). "Evaluation of the quality of red blood cell concentrates produced at the National Blood Transfusion Center of Lomé ". Pan Afr Med J. 32:171-176. doi:10.11604/pamj.2019.32.171.17680.

. KD. Yao , S. Kabore ,L. Siransy-Bogui ,B. Dembele ,KD. Kouakou ,S. Abisse , et al. (2014). "Quality control of labile blood products (LBP)"Contrôle qualité des Produits Sanguins Labiles (PSL) : experience of the National Blood Transfusion Center of Côte d'Ivoire from 2010 to 2013". Transfus Clin Biol. 21:246. doi:10.1016/j.tracli.2014.08.124.

. S. Upadhyay , T. Pangtey .(2016). "Quality Analysis of Blood Component (Prbc and Platelet Concentrates): a Study From a Tertiary Care Teaching Hospital of Kumaon Region of Uttarakhand". J Evol Med Dent Sci. 5:1210–1212.

. SG. Langreth , RT. Reese , MR. Motyl MR, W. Trager . (1979). "Plasmodium falciparum: Loss of knobs on the infected erythrocyte surface after long-term cultivation". Exp Psarasitol. 48:213–219.

. A. Khermach , H. Khalki ,L. Louzi ,A. Zinebi ,K. Moudden ,M. Elbaaj .(2017). " Biological disturbances during malaria: About thirty cases"Pan Afr Med J. 26:1–8.

. F. Baunaure , G. Langsley . (2005). "Trafic protéique dans le globule rouge infecté par Plasmodium." .Médecine/sciences.21:523–529. doi:10.1051/medsci/2005215523.

Downloads

Published

2022-04-06

How to Cite

Symphorien Ewodo, Jeannette Yondo, Audrey Divine Kianpi Sonhafouo, Clémence Olemba, Ongbayokolak, N. sylvie, Michel Nouboum, & Eveline Ngouadjeu Dongho. (2022). Impact of Plasmodial Parasitaemia on the Quality of Erythrocyte Concentrates Distributed at the Blood Transfusion Center of the Regional Hospital of Bafoussam-Cameroon. American Scientific Research Journal for Engineering, Technology, and Sciences, 87(1), 58–67. Retrieved from https://www.asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/7594

Issue

Vol. 87 No. 1 (2022)

Section

Articles

License

Authors who submit papers with this journal agree to the following terms.