Gas Chromatography-Spectrometric Analysis of An African Mistletoe Leaf Extract
Keywords:
Azardirachta indica, GCMS, leaf extract, methanol, Tapinanthus globiferusAbstract
The high prevalence of mood disorders and the failings of the current drugs for the treatment of these disorders call for renewed efforts to discover novel chemical entities to meet the disease demand of these clinical conditions. Methanol Tapianthus globiferus leaf extract has demonstrated anxiolytic activity in mice. However, reports on specific chemical components of the medicinal plant that may account for the anxiolytic and other biological effects are few. Thus, gas chromatography-mass spectrometric analysis was carried out on methanol Tapianthus globiferus leaf extract. The results include acetic acid, oxalic acid, isobutyl amine, N-ethyl formamide, ethanamine, o-allyl hydroxylamine, N, N-dimethyl ethanamine, dimethyl silane, 1-propanol, 2-propenenitrile, carbonyl sulfide, [3, 4-b] pyrazin-5 (4H)-one, 6-(1-pyrrolidinyl)-furanone, thiirane, urea and propenamide. These phytoconstituents are associated with important biological activities and may be responsible for the anxiolytic activity of the extract under investigation and some other pharmacological activities reported for extracts of Tapinanthus globiferus and its congeners. These findings are a justification for the traditional uses of Tapianthus globiferus for the management of diverse chronic diseases.
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