COVID-19: History, Etiology, Epidemiology, and Pathogenesis

Authors

  • Tsvetko Vasilev Grigorov Medical Faculty of Sofia Medical University 27, Nikolay Liliev Str, Sofia Bulgaria

Keywords:

COVID-19, SARS-CoV-2, 16s rRNA, S protein, M protein, N protein, antibodies, immune response, interleukins, lymphocytes, renin-angiotensin-aldosterone system

Abstract

The 2019 coronavirus disease (COVID-19) is an infectious disease caused by the virus SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). The first case of the disease was identified in Wuhan, China, in December 2019. The disease quickly spread around the world as a pandemic.

COVID-19 is transmitted by breathing in air droplets and other small particles that contain the virus. Infection occurs most often when people are in close proximity, but it can also happen at greater distances between them, especially indoors. Spread of the disease can also occur by entry of contaminated fluids into the eyes, nose, or mouth, and less commonly through contaminated surfaces. Affected individuals carry the virus for up to 20 days and can spread it even if they do not develop the disease symptoms.

References

ACR Recommendations for the use of Chest Radiography and Computed Tomography for Suspected COVID-19 Infection. American College of Radiology. 22 March 2020.

Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature, 2003, 426:450-454.

Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, March 2020.

Li W, Zhang C, Sui J, et al. Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J, 2005, 24, 1634-1643,.

Wrapp D, Wang N, Corbett KS, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science, 2020, 367, 1260-1263.

Immune responses and correlates of protective immunity against SARS-CoV-2. European Centre for Disease Prevention and Control, 2021. Retrieved 3 June 2021.

Cohen JI, Burbelo PD. Reinfection with SARS-CoV-2: Implications for Vaccines. Clinical Infectious Diseases, 2020. M 73 m (11), e4223–e4228. doi:10.1093/cid/ciaa1866. PMC 7799323. PMID 33338197. S2CID 229323810.

Zhao Z, Wei Y, Tao C. An enlightening role for cytokine storm in coronavirus infection. Clinical Immunology, 2021, 222, 108615. doi:10.1016/j.clim.2020.108615. PMC 7583583. PMID 33203513.

Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. Journal of Pharmaceutical Analysis, 2020, 10 (2), 102–108. doi:10.1016/j.jpha.2020.03.001. PMC 7104082 PMID 32282863.

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Published

2023-03-30

How to Cite

Grigorov, T. V. . (2023). COVID-19: History, Etiology, Epidemiology, and Pathogenesis. American Scientific Research Journal for Engineering, Technology, and Sciences, 92(1), 153–159. Retrieved from https://www.asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/8671

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Articles