Phytochemical Composition and Brine Shrimp Cytotoxicity Effect of Rosmarinus officinalis

Authors

  • Z. N. Kabubii University of Nairobi,kENYA
  • J. M. Mbaria
  • P. M. Mbaabu

Keywords:

Artemia salina, bioactive, cytogenic, extract, lethal concentration, mortality

Abstract

Plant compounds exhibit enormous structural diversity, unfortunately only a small proportion of that diversity has been seriously explored for pharmacological potential. The use and commercialization of non-timber plant products which include medicinal plants has been found to be an important livelihood strategy in developing countries especially for the rural people. The current study was carried out on the crude aqueous extracts of leaves of Rosmarinus officinalis (rosemary) to evaluate the plants phytochemical composition using standard methods. The cytotoxicity and lethality  effects on the  brine shrimp (Artemia salina)  of four organic extracts  and  also an aqueous extract of the rosemary leaves was  studied using  three concentrations (10, 100, 1000 ) µg/ml. The data was analyzed using Finney’s probit analysis method with the help of Biostat 2009. The phytochemical analysis showed presence of; terpenoids, tannins, cardiac glycosides, flavonoids, reducing sugars and saponins. All the extracts gave moderate medial lethal concentration (LC 50) between 220 and 470 µg/ml. Cytogenic compounds in the extract caused the brine shrimp high lethality which corroborates the wide use of rosemary in the health care. Rosemary plant could be seen as a good source for useful drugs.

 

Author Biography

Z. N. Kabubii, University of Nairobi,kENYA

 Senior Technologist,department of Biochemistry/

Msc student department of Public Heaith,Pharmacologyand Toxicology

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Published

2015-03-04

How to Cite

Kabubii, Z. N., Mbaria, J. M., & Mbaabu, P. M. (2015). Phytochemical Composition and Brine Shrimp Cytotoxicity Effect of Rosmarinus officinalis. American Scientific Research Journal for Engineering, Technology, and Sciences, 11(1), 127–135. Retrieved from https://www.asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/589