Potential ABTS Reducing and Anti-collagenase Activity of Scutellarein and Apigenin
AbstractIn developed and developing countries, the aging population growth rapidly and the consumption of natural product which rich antioxidant increasing. The aim of this study was to investigate the ABTS reducing activity and anti-collagenase activity of scutellarein and apigenin. This study used ABTS reducing activity for antioxidant assay and collagenase inhibitory activity for antiaging assay. Scutellarein (16.77 μg/ml) has higher antioxidant activity through ABTS reducing activity compared with apigenin (80.19 μg/ml). Scutellarein (99.20 μg/ml) has higher antiaging activity through collagenase inhibitory activity compared with apigenin (211.67 μg/ml). Scutellarein has very strong antioxidant activity through ABTS reduction activity and strong antiaging property particularly as collagenase inhibitor. Apigenin has strong antioxidant activity through ABTS reduction activity and weak antiaging property particularly as collagenase inhibitor.
AW. Pathath. “Theories of aging”. The International Journal of Indian Psychology, vol. 4(3), pp. 15-22. 2017.
YH. Huang, PY. Wu, KC. Wen, CY. Lin and HM. Chiang. “Protective effects and mechanisms of Terminalia catappa L. methanolic extract on hydrogen-peroxide-induced oxidative stress in human skin fibroblast”. BMC Complementary and Alternative Medicine, vol. 18(266), pp. 1-9. 2018.
Djohan, Kristina, AH. Henderson, INE. Lister, E. Girsang and E. Fachrial. “Comparison of antioxidant and anti-hyaluronidase activity of tomato (Solanum lycopersicum L.) extract and lycopene”. ASRJETS, vol. 52(1), pp. 49-56. 2019.
ACM. Arango, SVF. Munoz and G. Sanclemente. “Mechanisms of Skin Aging”. IATREIA, vol. 30(2), pp. 160-70. 2017.
U. Panich, G. Sittithumcharee, N. Rathviboon and S. Jirawatnotai. “Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging”. Stem Cells International, vol. 2016, pp. 1-14. 2016.
S. Zhang and E. Duan. “Fighting against skin aging: The way from bench to beside”. Cell Transplantation, vol. 27(5), pp. 729-38. 2018.
C. Simioni, G. Zauli, AM. Martelli, M. Vitale, G. Sacchetti, A. Gonelli and LM. Neri. “Oxidative stress: Role of physical exercise and antioxidant nutraceuticals in adulthood and aging”. Oncotarget, vol. 9(24), pp. 17181-98. 2018.
M. Sardarodiyan and AM. Sani. “Natural antioxidants: Sources, extraction and application in food systems”. Nutrition & Food Science, vol. 46, pp. 363-73. 2016.
WD Fitriana, S. Fatmawati and T. Ersam. “Uji aktivitas antioksidan terhadap DPPH dan ABTS dari fraksi-fraksi daun kelor (Moringa oleifera)”. Prosiding Simposium Nasional Inovasi dan Pembelajaran Sains, Bandung, Indonesia, 2015.
A. Nurrochmad, Wirasti, A. Dirman, E. Lukitaningsih, A. Rahmawati and N. Fakhrudin. “Effects of antioxidant, anti-collagenase, anti-elastase, anti-tyrosinase of the Extract and Fraction from Turbinaria decurrens Bory”. Indonesian J. Phar, vol. 29(4), pp. 188-97. 2018.
L. Yulianti, E. Mardliyati, K. Bramono, HJ. Freisleben. “Asiaticoside induces cell proliferation and collagen synthesis in human dermal fibroblasts”. Univ Med, vol. 34(2), pp. 96-103. 2015.
MA. Ch, SB Naz, A. Sharif, M Akram and MA. Saeed. “Biological and Pharmalogical Properties of the Sweet Basil (Ocimum basilicum)”. BJPR, vol. 7(5), pp. 330-9. 2015.
S. Zhara and Y. Iskandar. “Review artikel: Kandungan senyawa kimia dan bioaktivitas Ocimum Basilicum L”. Farmaka, vol. 15(3), pp. 143-52. 2017.
EPG. Grijalva, MAP. Salas, NL Lopez, MSC. Mendoza, GV. Olivo and JB. Heredia. “Flavonoids and phenolic acids from oregano: Occurrence, biological activity and health benefits”. Plants, vol. 7(2), pp. 1-23. 2018.
VE. Arterbery, S. Gupta. “Apigenin as an anti-aging skin treatment”. J. Clin. Cosmet. Dermtol, vol. 2(2), pp.1-8. 2018.
T. Gu, Y. Zhong, YT. Lu, Y. Sun, ZX. Dong, WY Wu, ZH. Shi, NG. Li, X. Xue, F. Fang, HM Li and YP. Tang. “Synthesis and bioactivity characterization of scutellarein sulfonated derivative”. Molecules, vol. 22(1028), pp. 1-8. 2017.
W. Widowati, N. Fauziah, H. Herdiman, M. Afni, E. Afifag, HSW. Kusuma, H. Nufus, S. Arumwardana and DD. Rihibiha. “Antioxidant and anti aging assays of Oryza Sativa extract, vanillin and coumaric acid”. Journal of Natural Remedies, vol. 16(3), pp. 88-99. 2016.
Q. Liu, X. Li, X. Ouyang and D. Chen. “Dual effect of glucuronidation of a Pyrogallol-type phytophenol antioxidant: A comparison between scutellarein and scutellarin”. Molecules, vol. 23(3225), pp. 1-13. 2018.
CA. Martinez, OM. Mosquera and J. Nino. “Apigenin glycoside: an antioxidant isolated from Alchornea coelophylla pax & k. Hoffm. (euphorbiaceae) leaf extract”. Univ. Sci, vol. 21(3), pp. 245-57. 2016.
M. Gulluce, F. Orhan, D. Yanmis, T. Arasoglu, Z. Guvenalp and LO. Demirezer. “Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genetoxic potency”. Toxicol. Ind. Health, vol. 31(9), pp. 1-10. 2013.
Kristina, AH. Henderson, Djohan, INE. Lister, E. Girsang and E. Fachrial. “Antioxidant and anticollagenase activity of tomato (Solanum lycopersicum L.) and lycopene”. ASRJETS, vol. 52(1), pp. 57-66. 2019.
W. Widowati, AP. Rani, RA. Hamzah, S. Arumwardana, E. Afifah, HSW. Kusuma, DD. Rihibiha, H. Nufus and A. Amalia. “Antioxidant and antiaging assays of Hibiscus sabdariffa extract and its compounds”. Natural Product Sciences, vol. 23(3), pp. 192-200. 2017.
A. Arterbery, S. Gupta. “Apigenin as an anti-aging skin treatment”. J. Clin. Cosmet. Dermatol, vol. 2(2), pp. 1-8. 2018.
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