The Effectiveness of Peperomia Pellucida Extract Against Acne Bacteria
Keywords:Peperomia pellucida, Propionibacterium acnes, Anti-Bacterial, Agar Diffusion
Background: Acne vulgaris is a common inflammatory condition in the pilosebaceous unit that occurs in adolescents and young adults characterized by blackheads, papules, pustules, nodules. Among all of these bacteria, Propionibacterium acnes have the most important role in the pathogenesis of acne. Some leaves called tumpangan air (Peperomia pellucida) are one type of plant that is widely used for treatment. This leaf has various pharmaceutical effects includes antimicrobial, anticancer, antipyretic, anti-inflammatory, antioxidant, analgesic, and anti-oedematogenic activities. Objective: This study was aimed to examine the effectiveness of Peperomia pellucida in inhibiting the growth of Propionibacterium acne bacteria. Methods: Evaluation of antibacterial used agar diffusion method Which used ethanol extract of Peperomia pellucida (0.3 gr/ml, 0.5 gr/ml, 0.7 gr/ml and 1 gr/ml) as samples, gentamycin as positive, and DMSO as the negative control. Results: The higher concentration show higher antibacterial activity against Propionibacterium acne while the average of inhibition zone for 0.3 gr/ml, 0.5 gr/ml, 0.7 gr/ml and 1 gr/ml of ethanol extract from Peperomia pellucida were 9.53mm, 10.53mm, 0.7mm, 13.36 mm, and 15.70 mm, respectively. Conclusion: With the results, can be concluded that Peperomia pellucida extracts are anti-bacterial to inhibit the growth of Propionibacterium acnes bacteria.
H. Nasri, M. Bahmani, N. Shahinfard, A. M. Nafchi, S. Saberianpour, and M. R. Kopaei, ‘Medicinal plants for the treatment of acne vulgaris: A review of recent evidences’, Jundishapur J. Microbiol., vol. 8, no. 11, pp. 1–9, 2015.
A. Hariana, Tumbuhan Obat dan Khasiatnya Seri 3. Jakarta: Penembar Swadaya, 2011.
A. A. M. D. D. N. Amarathunga and S. U. Kankanamge, ‘a Review on Pharmacognostic, Phytochemical and Ethnopharmacological Findings of Peperomia Pellucida (L.) Kunth: Pepper Elder’, Int. Res. J. Pharm., vol. 8, no. 11, pp. 16–23, 2017.
R. U. Egwuche, A. A. Odetola, and O. Erukainure, ‘Preliminary Investigation into the Chemical Properties of Peperomia pellucida L.’, Res. J. Phytochem., vol. 5, pp. 48–53, 2011.
P. Majumder, ‘Phytochemical, Pharmacognostical, and Physicochemical Standardization of Peperomia pellucida (L.) HBK.’, Int. J. Compr. Pharm., vol. 8, no. 6, pp. 1–4, 2011.
H. Sheikh, S. Sikder, S. K. Paul, A. M. R. Hasan, M. Rahaman, and S. P. Kundu, ‘Hypoglicemic, Anti-Inflammatory and Analgesic Activity of Peperomea Pellucida (L.) HBK (Piperaceae)’, IJPSR, vol. 4, no. 1, pp. 458–463, 2013.
S. Xu, N. Li, M.-M. Ning, C.-H. Zhou, Q.-R. Yang, and M.-W. Wang, ‘Bioactive Compounds from Peperomia pellucida’, J. Nat. Prod., vol. 69, no. 2, pp. 247–250, Feb. 2006.
P. Majumder, P. Abraham, and S. V, ‘Ethno-medicinal, Phytochemical and Pharmacological review of an amazing medicinal herb Peperomia pellucida (L.) HBK.’, Res. J. Pharm. Biol. Chem. Sci., vol. 2, no. 4, pp. 358–364, 2011.
L. S. Wei, W. Wee, J. Yong, F. Siong, and D. F. Syamsumir, ‘Characterization of Anticancer , Antimicrobial , Antioxidant Properties and Chemical Compositions of Peperomia pellucida Leaf Extract’, Acta Med. Iran., vol. 49, no. 10, pp. 3–7, 2011.
E. Platsidaki and C. Dessinioti, ‘Recent advances in understanding Propionibacterium acnes (Cutibacterium acnes) in acne [version 1; referees: 2 approved]’, F1000Research, vol. 7, no. 0, 2018.
N. Milah, S. H. Bintari, and D. Mustikaningtyas, ‘Pengaruh Konsentrasi Antibakteri Propolis terhadap Pertumbuhan Bakteri Streptococcus pyogene s secara In Vitro’, Life Sci., vol. 5, no. 2, pp. 95–99, 2016.
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