UV Spectrophotometric Determination of Luliconazole Semisolid Dosage Form

Authors

  • Sumitra Shrestha M.Pharm (Clinical pharmacy) Pokhara University, Assistant Quality Assurance Manager, Divine Healthcare Pvt. Ltd. Bharatpur-16
  • Sonu Pakhrin M.Pharm (Clinical pharmacy) Pokhara University, Quality Control Officer Divine Healthcare Pvt. Ltd. Bharatpur-16
  • Sangit Maharjan B.Pharm Shree medical & Technical College, Production Officer Divine Healthcare Pvt. Ltd. Bharatpur-16
  • Ranjana GC B.Pharm, Lttile Buddha College of Health Science, Assistant Quality Control Manager, Divine healthcare Pvt. Ltd, Bharatpur-16, Nepal
  • Sagarananda Giri M.Pharm (Clinical pharmacy) Pokhara University, Pokhara Kaski, Nepal
  • Naresh Thapa B.Pharm Dhaka University Bahgladesh, Manager Quality Assurance, Divine Healthcare Pvt. Ltd, Bharatpur-16
  • Dr. Jeevan Raj Shrestha B.SC Microbiology (Tribhuvan University), MBBS (Manipal College of Medical Sciences, Pokhara), Kathmandu University, Medical Officer Barhabise Primary Health Centre, Barhabise-9

Keywords:

UV Spectrophotometry, Luliconazole

Abstract

Luliconazole mostly prescribed drug for the management of superficial problems, the very simple, Fast, accurate and economical methods have been proposed for the determination of Luliconazole cream. Luliconazole  was measured by using Uv spectroscopy method with the solution of mrthanol and purified water the linearity was found to be 0.9987 and the accuracy showed mean % RSD of 0.921776 and with total meam % RSD 1.10130 in intermediate precision, robustness %RSD 0.543539 all the paranmeters values were within standard limit thus Analytical method was validated according to ICH guideline for the determination of Luliconazole cream. The method was found to be precise and validated as per ICH guidelines.

References

. Havlickova B, Czaika VA, Friedrich M (2008) Epidemiological trends in skin mycoses world wide. Mycoses 51(4): 2-15.

. Aditi M, Anju G. Method development and validation of RP HPLC method for assay and related substances of Luliconazole in topical dosage form. International Journal of Pharmaceutical Chemistry and Analysis. 2017; 4(2): 46-50.

. https://www.drugs.com/luzu.html.

. Uchida, K., Nishiyama, Y. and Yamaguchi, H. In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent. Journal of Infection and Chemotherapy, 2004; 10(4):216-219.

. Scher, R. K., Nakamura, N. and Tavakkol, A. Luliconazole: a review of a new antifungal agent for the topical treatment of onychomycosis. Mycoses, 2014; 57(7) 389- 393.

. Niwano Y, Koga H, Kodama H, Kanai K, Miyazako T, Yamaguchi H. Inhibition of sterol 14α-demethylation of Candida albicans with NND-502, a novel optically active imidazole antimycotic agent. Med Mycol, (1999); 37:321–5.

. https://www.drugs.com/luzu.html.

. Zargaran, M., Taghipour, S., Kiasat, N., Aboualigalehdari, E., Rezaei Matehkolaei, A., Mahmoudabadi, A. Z. and Shamsizadeh, F. Luliconazole, an alternative antifungal agent against Aspergillus terreus. Journal de Mycologie Médicale, 2017; 27(3):351-356.

. Luliconazole, FDA, Available at https://www.accessdata.fda.gov/drugsatfda_do cs/label/2013/204153s0.

. Luliconazole, Accession No. DB08933, Available at https://www.drugbank.ca/drugs/DB08933 [Accessed 27 rebmetpeS2017].

. Marek A Wolter M. K. Leahy L. Geisler, N. Nakamura. Development of an LC-MS/MS Method for the Determination of the Antifungal Luliconazole in Human Toenails. American Association of Pharmaceutical Scientists, DOI:10.13140/RG.2.2.22476.51847. (2013).

. Malasiya A, Goyal A. Method Development and Validation of RP HPLC Method for Assay and related Substances of Luliconazole in Topical Dosage form. International Journal of Pharmaceutical Chemistry and Analysis, (2017); 4(2):46-50.

. SRTambe, Sawanth SD, Bhonsle AP. Estimation of Luliconazole in Formulation and Biofluid. J Anal Pharm Res, (2017); 6(5): 00187.

. Chaudhari MJ, Chaudhari SR, Chalikwar SC, Shirkhedkar AA. Application of area under curve technique for UVSpectrophotometric determination of Luliconazole in bulk and pharmaceutical formulation. Asian J. Pharm. Ana, (2018); 8(1):45-48

Downloads

Published

2021-03-08

How to Cite

Shrestha, S. ., Pakhrin, S. ., Maharjan, S. ., GC, R. ., Giri, S. ., Thapa, N. ., & Shrestha, D. J. R. . (2021). UV Spectrophotometric Determination of Luliconazole Semisolid Dosage Form. American Scientific Research Journal for Engineering, Technology, and Sciences, 77(1), 161–171. Retrieved from https://www.asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/6679

Issue

Section

Articles