Mini Review: Chemical Characterization and Evaluation of Antiviral and Antibacterial Activity of Extracts from Graptopetalum paraguayense E. Walther (Crassulaceae)


  • Petia Genova-Kalou National Centre of Infectious and Parasitic Diseases (NCIPD), Virology Department, 44A “Gen. Stoletov” Blvd., 1233 Sofia, Bulgaria
  • Stefka Krumova National Centre of Infectious and Parasitic Diseases (NCIPD), Virology Department, 44A “Gen. Stoletov” Blvd., 1233 Sofia, Bulgaria
  • Maya M. Zaharieva Department of Infectious Microbiology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Nadezhda Markova Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria


Graptopetalum paraguayense E. Walther (GP), pharmacological perspectives, anti-herpes simplex virus effect, cell culture, toxicity


Graptopetalum paraguayense E. Walther (GP) is a traditional Chinese herbal medicine belonging to the Crassulaceae family As herbal medicine, GP possesses several biological/pharmacological perspectives. It was found that GP aqueous extracts exhibit anti-inflammatory and hepatoprotective, antioxidant, anti-hypertensive and antihyperglycemic, immunomodulatory, antineoplastic, antiviral and antibacterial activities. The GP contains in the high range levels phenolic compounds and anthocyanins. Despite the intense study of the plant, little data exist regarding its chemical composition. It was found that the GP aqueous extract has no cytotoxic effect on RD and Lep cells. The extract effectively inhibited herpes simplex virus (HSV) replication in dose-dependent manner moderate activity as well as Gram-positive bacterial strains.


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How to Cite

Petia Genova-Kalou, Stefka Krumova, Maya M. Zaharieva, & Nadezhda Markova. (2022). Mini Review: Chemical Characterization and Evaluation of Antiviral and Antibacterial Activity of Extracts from Graptopetalum paraguayense E. Walther (Crassulaceae). American Scientific Research Journal for Engineering, Technology, and Sciences, 85(1), 301–312. Retrieved from